[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8

[Arg8]-α-Neo-Endorphin (1-8) is a synthetic analog of the endogenous opioid peptide α-Neoendorphin, specificसबैy engineered with an arginine substitution at position 8 to enhance receptor binding affinity and metabolic stability. This octapeptide retains the core Tyr-Gly-Gly-Phe opioid motif, सबैowing it to interact potently with κ-opioid receptors (KOR) and μ-opioid receptors (MOR) in the central nervous system. It is primarily utilized in biochemical reखोजी as a stable tool compound for investigating pain pathways, stress responses, and the structure-activity relationships (SAR) of dynorphin-derived peptides.



TECHNICAL SPECIFICATIONS


Item
Specification
परिणाम नाम
[Arg8]-a-Neo-Endorphin (1-8)
CAS NO.
75106-72-8
Appearance
White to off-white lyophilized powder
Molecular Formula
C₄₆H₇₃N₁₅O₁₀
Molecular Weight
1036.2g/mol
Purity (RP-HPLC)
≥98% 
Solubility

Soluble in 1M acetic acid, DMSO, or deionized water

Endotoxin
≤1 EU/mg 
Biological Activity
Potent agonist for κ-opioid receptors (KOR)
Storage Conditions
Store at -20°C, protected from light and moisture
Stock स्थान
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

The peptide functions as a potent agonist at G protein-coupled opioid receptors, with a pronounced preference for the κ-opioid receptor (KOR) subtype. Upon binding, it inhibits adenylate cyclase activity, reducing intracellular cAMP levels and leading to neuronal hyperpolarization via the opening of potassium channels. This mechanism effectively suppresses neurotransmitter release (e.g., glutamate and substance P) in pain-processing pathways, resulting in antinociceptive and potential dysphoric effects characteristic of KOR activation.

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2.परिणाम INDICATIONS

This परिणाम is strictly for Reखोजी Use Only (RUO) and is indicated for in vitro and preclinical studies targeting the opioid system. It is ideal for scientists in neuropharmacology and drug discovery who require a stable, high-affinity ligand for receptor binding assays, functional cAMP accumulation tests, and animal model studies of analgesia. The [Arg8] modification makes it particularly suitable for experiments requiring enhanced enzymatic stability compared to the native peptide sequence.

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3.CLINICAL EFFICACY OF परिणाम

As a reखोजी chemical, [Arg8]-α-Neo-Endorphin (1-8) is not intended for human therapeutic use and has no approved clinical efficacy data. In experimental settings, this analog demonstrates superior and prolonged analgesic efficacy in rodent models of inflammatory and neuropathic pain compared to unmodified fragments. Its enhanced stability translates to longer-lasting behavioral effects, providing robust preclinical data for the development of novel opioid-based therapeutics.

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4.प्रमाणपत्र

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide पानी, adhering strictly to quality standards and obtaining internationसबैy recognized प्रमाणीकरणs.


हाम्रो उत्पादनion partners सबै employ GMP-compliant परिणामion systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of परिणाम comes with complete documentation, including a प्रमाणपत्र of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and reखोजी-grade peptide पानी to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging समाधान to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the परिणाम.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the परिणामion and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The दल invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA प्रमाणीकरणs, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality पानी and superior services.


We focus on the reखोजी and development and supply of high-quality chemical पानी, strictly adhering to international standards and quality systems. हाम्रो उत्पादनs are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific reखोजी, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


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If you have any परिणाम requirements, please पठाउनु an इमेज to:support@huanqiukeji9.com;Whatsapp:85244969439

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